Microsoft Technology Licensing Assigned Two Patents

Multiplex similarity search in DNA data storage
Microsoft Technology Licensing, LLC, has been assigned a patent (12430567) developed by Chen; Yuan-Jyue, Taipei, Taiwan, and Strauss; Karin, Seattle, WA, for a “multiplex similarity search in DNA data storage.“

The abstract of the patent published by the U.S. Patent and Trademark Office states: “Multiplex similarity search can be performed in a DNA data storage context. The described technologies can support a plurality of different DNA data storage queries in a single query run. A linking strand can be used to connect a query to its matching data element. After the query finds a matching data element, a result strand can be sequenced to the reveal the matching data element as well as which of the queries resulted in the match. Thus, in a multiplex similarity search scenario, a plurality of result strands from a single query run can be correlated to a plurality of different queries. Also, the result strand can be of significantly longer length than both the unmatched data strands and the unmatched query strands. Therefore, filtering based on length can provide more accurate results.”

The patent application was filed on 2019-08-14 (16/540812).

Silica encapsulated DNA on magnetic nanoparticles
Microsoft Technology Licensing, LLC, has been assigned a patent (12410423) developed by Strauss; Karin, Seattle, WA, Chen; Weida, Grass; Robert, Kohll; Alexander Xavier Christof, Zürich, Switzerland, and Nguyen; Bichlien Hoang, Seattle, WA, for a “silica encapsulated DNA on magnetic nanoparticles.“

The abstract of the patent published by the U.S. Patent and Trademark Office states: “A data storage medium is disclosed comprising a substrate covered with alternating layers of a polycationic molecule and artificially synthesized DNA molecules encoding digital information. The magnetic substrate may be a metallic nanoparticle formed from a metal such as iron or cobalt. The polycationic molecule may be polyethyleneimine (PEI). The DNA is protected from degradation by encapsulation in silica. A process for stably storing DNA is also disclosed. Stored DNA may be freed from the silica for sequencing or other analysis by washing the silica-coated DNA with a buffered hydrogen fluoride solution. Storage densities of more than 7% DNA by weight are achieved on nanoparticles.”

The patent application was filed on 2021-06-07 (17/341206).