R&D: Preservation and Encryption in DNA Digital Storage

ChemPlusChem has published an article written by Yi Zhang, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 P. R. China, Yubin Ren, Department of Chemistry, Tsinghua University, Beijing, 100084 P. R. China, Yangyi Liu, Department of Chemistry, Tsinghua University, Beijing, 100084 P. R. China, Dr. Fan Wang, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 P. R. China, Prof. Hongjie Zhang, Prof. Kai Liu, State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 P. R. China, and Department of Chemistry, Tsinghua University, Beijing, 100084 P. R. China.

Abstract: “DNA-based data storage is regarded as the optimal next-generation information storage strategy. This Review summarizes the recent advances in preservation method of DNA data storage, including in vivo, in vitro and protective storage. Meanwhile, information encryption and steganography based on different preservation strategies are also highlighted.“

“The exponential growth of the total amount of global data presents a huge challenge to mainstream storage media. The emergence of molecular digital storage inspires the development of the new-generation higher-density digital data storage. In particular, DNA with high storage density, reproducibility, and long recoverable lifetime behaves the ideal representative of molecular digital storage media. With the development of DNA synthesis and sequencing technologies and the reduction of cost, DNA digital storage has attracted more and more attention and achieved significant breakthroughs. Herein, this Review briefly describes the workflow of DNA storage, and highlights the storage step of DNA digital data storage. Then, according to different information storage forms, the current DNA information encryption methods are emphatically expounded. Finally, the brief perspectives on the current challenges and optimizing proposals in DNA information preservation and encryption are presented.“